Serum factor B and Activated C3b (activated C3 will continuosly activate the complement system)
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C3bB
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Note: C3b is inactivated by factors H and I. But the introduction of LPS and other substances protects C3b from H and I hence C3b will be activated
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Activate serum factor D
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Cleavage of factor B
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C3bBb (stabilised by properdin) acts as a C3 convertase [this is where classical, alternative and lectin pathway meet]
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*Convertase activate C3
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(2 arrows forming C3a) C3b
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C3b and C4b2b forms C5 convertase
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(2 arrows forming C5a) C5b
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C5b bind C6 and C7
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Gather C8, forms small pores
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Forms pores with C9 [formation of the Membrane Attack Complex (MAC)]
*One C3 convertase can actually cleave many C3, this is thus the amplification step
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