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Tuesday, October 12, 2004

Alternative Pathway

Serum factor B and Activated C3b (activated C3 will continuosly activate the complement system)

C3bB

Note: C3b is inactivated by factors H and I. But the introduction of LPS and other substances protects C3b from H and I hence C3b will be activated

Activate serum factor D

Cleavage of factor B

C3bBb (stabilised by properdin) acts as a C3 convertase [this is where classical, alternative and lectin pathway meet]

*Convertase activate C3

(2 arrows forming C3a) C3b

C3b and C4b2b forms C5 convertase

(2 arrows forming C5a) C5b

C5b bind C6 and C7

Gather C8, forms small pores

Forms pores with C9 [formation of the Membrane Attack Complex (MAC)]



*One C3 convertase can actually cleave many C3, this is thus the amplification step

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